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This study presents an investigation of antifungal properties of hybrid materials based on silica, hydroxypropyl cellulose and ZnSO4.7H2O. The hybrid materials were synthesized by sol-gel technique and as a source of silica was used tetraethylortho silicate (TEOS). The quantity of organic substance was 5 wt. % and the zinc concentration varied from 0,5 to 5 wt. %. The strain that was used for determination of potential antifungal activity of materials was Candida albicans 74. The first experiment was focused on counting the survived cells after contact of fungi and materials with different zinc concentrations. The results show that the zinc amount and the cultivation time influence the number of colonies. The second method was based on measuring the free zone of fugal growth formed around well with materials. It was examined that the zone size depends on the amount of zinc ions in the materials.
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