Bioactive components of donkey milk Bioactive components of donkey milk
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Abstract
Recently, donkey milk has received a lot of interest due to its similarity to human milk in terms of protein, lactose and milk fat content. The purpose of this review is to summarize the knowledge of research done on the composition of milk, including its functionality and potential therapeutic use. Donkey milk is suitable for use in children who are allergic to cow's milk. The bioactive components contained in donkey milk have antibacterial, antiviral and antifungal effects, as well as anti-inflammatory and antioxidant properties
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Addo C.N.A., Ferragut, V. Evaluating the ultra-high pressure homogenization (UHPH) and pasteurization effects on the quality and shelf life of donkey milk. International Journal of Food Studies, 2015, 4(1): 104-115. https://doi.org/10.7455/ijfs/4.1.2015.a9
Alabiso M., Giosuè C., Alicata M. L., Mazza F., Iannolino G. The effects of different milking intervals and milking times per day in jennet milk production, Animal, 2008, 3(4): 543-547. https://doi.org/10.1017/S1751731108003753
Alichanidis E., Moatsou G., Polychroniado A. Composition and Properties of Non-cow Milk and Products. In: Non-Bovine Milk and Milk Products. (E. Tsakalidou, K. Papadimitriou Eds.). Elsevier Academic Press. 2016, pp. 81-116, eBook ISBN: 9780128033623 https://doi.org/10.1016/B978-0-12-803361-6.00005-3
Altomonte I., Nardoni S., Mancianti F., Perrucci S., Licitra R., Salari F., Martini M. Preliminary results on antifungal activity of donkey milk. Large Animal Review, 2019a, 25(5): 179-181.
Altomonte I., Salari F., Licitra R., Martini M. Donkey and human milk: Insights into their compositional similarities. International Dairy Journal, 2019, 89(2): 111-118. https://doi.org/10.1016/j.idairyj.2018.09.005
Amati L., Marzulli G., Martulli M., Tafaro A., Jirillo F., Pugliese V., Martemucci G., D’Alessandro A. Donkey and goat milk intake and modulation of the human aged immune response. Current Pharmaceutical Design, 2010, 16(7): 864-869. https://doi.org/10.2174/138161210790883651
Aspri M., Economou N., Papademas P. Donkey milk: An overview on functionality, technology, and future prospects. Food Reviews International, 2017, 33(3): 316-333. https://doi.org/10.1080/87559129.2016.1175014
Aspri M., Leni G., Galaverna G., Papademas P. Bioactive properties of fermented donkey milk, before and after in vitro simulated gastrointestinal digestion. Food Chemistry, 2018, 268(2): 476-484 https://doi.org/10.1016/j.foodchem.2018.06.119
Barłowska J., Szwajkowska M., Litwińczuk Z., Król J., Nutritional value and technological suitability of milk from various animal species used for dairy production, 2011, Comprehensive Reviews in Food Science and Food Safety, 10(6): 291-302. https://doi.org/10.1111/j.1541-4337.2011.00163.x
Brumini D., Criscione A., Bordonaro S., Vegarud G. E., Marletta D. Whey proteins and their antimicrobial properties in donkey milk: a brief review. Dairy Science and Technology, 2015, 96(1): 1-14. https://doi.org/10.1007/s13594-015-0246-1
Carminati D., Tidona F. 2017. Chapter 31. Nutritional value and potential health benefits of donkey milk. In: Nutrients in Dairy and their Implications for Health and Disease (R. R. Watson, R. J. Collier, V.R. Preedy Eds.). Elsevier Inc., Academic Press. 2017. pp. 407-414, Hardcover ISBN: 978-0-12-809762-5, eBook ISBN: 978-0-12-809763-2,
Cavallarin L., Giribaldi M., de los Rio D. S., Valle E., Barbarino G., Gennero M. S., Civera T. A survey on the milk chemical and microbiological quality in dairy donkey farms located in NorthWestern Italy. Food Control, 2015, 50(4): 230-235. https://doi.org/10.1016/j.foodcont.2014.08.019
Chiavari C., Coloretti F., Nanni M., Sorrentino E., Grazia L. Use of donkey’s milk for a fermented beverage with lactobacilli. Le Lait, 2005, 85(6): 481-490. https://doi.org/10.1051/lait:2005031
Criscione A., Cunsolo V., Bordonaro S., Guastella A. M., Saletti R., Zuccaro A., D’Urso G., Marletta D. Donkeys’ milk protein fraction investigated by electrophoretic methods and mass spectrometric analysis. International Dairy Journal, 2009, 19(4): 190-197. https://doi.org/10.1016/j.idairyj.2008.10.015
D’Alessandro A. G., Martemucci G., Jirillo E., De Leo V. Major whey proteins in donkey’s milk: effect of season and lactation stage. Implications for potential dietary interventions in human diseases. Immunopharmacology and Immunotoxicology, 2011, 33(2): 259-265. https://doi.org/10.3109/08923973.2010.499365
Ebrahimi A., Moosavy M., Khatibi S.A., Barabadi Z., Hajibemani A. A comparative study of the antibacterial properties of milk from different domestic animals. International Journal of Dairy Technology, 2021, 74(2): 425-430. https://doi.org/10.1111/1471-0307.12757
Fantuz F., Ferraro S., Todini L., Pilonia R., Mariani P., Salimei E. Donkey milk concentration of calcium, phosphorus, potassium, sodium and magnesium, International Dairy Journal, 2012, 24(2): 143-145. https://doi.org/10.1016/j.idairyj.2011.10.013
Feng P., Gao M., Burgher A., Zhou T.H., Pramuk K. A nine-country study of the protein content and amino acid composition of mature human milk. Food & Nutrition Research, 2016, 60(8): 31042. https://doi.org/10.3402/fnr.v60.31042
Gastaldi D., Bertino E., Monti G., Baro C., Fabris C., Lezo A., Medana C., Baiocchi C., Mussap M., Galvano F., Conti A. Donkey’s milk detailed lipid composition. Frontiers in Bioscience, 2010, 2(2): 537-546. https://doi.org/10.2741/E112
Giosuè C., Alabiso M., Russo G., Alicata M. L., Torrisi C. Jennet milk production during the lactation in a Sicilian farming system. Animal, 2008, 2(10): 1491-1495. https://doi.org/10.1017/S1751731108002231
Gubić J., Tasić T., Tomić J., Torbica A. Determination of whey proteins profile in Balkan donkey’s milk during lactation period. Journal of Hygienic Engineering and Design 2014, 8(1): 178-180. Available at: https://keypublishing.org/jhed/wp-content/uploads/2020/07/11.-Jasmina-Gubić.pdf
Guo H. Y., Pang K., Zhang X. Y., Zhao L., Chen S. W., Dong M. L., Ren F. Z. Composition, physiochemical properties, nitrogen fraction distribution, and amino acid profile of donkey milk. Journal of Dairy Science, 2007, 90(4): 1635-1643. https://doi.org/10.3168/jds.2006-600
Ibrahim H.R., Aoki T. New promises of lysozyme as immune modulator and antimicrobial agent for nutraceuticals. Foods & Food Ingredients Journal of Japan, 2003, 208(5): 361-374.
Ivanković A., Ramljak J., Štulina I., Antunac N., Bašić I., Kelava N., Konjačić M. Characteristics of the lactation, chemical composition and milk hygiene quality of the Littoral-Dinaric ass. Mljekarstvo, 2009, 59(2): 107-113.
Jiang L., Lv J., Liu J., Hao X., Ren F., Guo H. Donkey milk lysozyme ameliorates dextran sulfate sodium-induced colitis by improving intestinal barrier function and gut microbiota composition. Journal of Functional Foods, 2018, 48(9): 144-152. https://doi.org/10.1016/j.jff.2018.07.005
Jirillo F., Magrone T. Anti-inflammatory and anti-allergic properties of donkey’s and goat’s milk. Endocrine, Metabolic & Immune Disorders - Drug Targets, 2014, 14(1): 27-37. https://doi.org/10.2174/1871530314666140121143747
Kapila R., Sharma R., Kapila S. Chapter 22. Milk and Fermented Milk Products in Alleviation of Aging Pathophysiology. In: Dairy in Human Health and Disease Across the Lifespan (R. R. Watson, R. J. Collier, V. R. Preedy Eds). Elsevier, Academic Press. 2017, pp. 287-292, Print ISBN 978-0-12-809868-4 https://doi.org/10.1016/B978-0-12-809868-4.00022-4
Karami Z., Akbari-adergani B. Bioactive food derived peptides: A review on correlation between structure of bioactive peptides and their functional properties. Journal of Food Science and Technology, 2019, 56(2): 535-547. https://doi.org/10.1007/s13197-018-3549-4
Kim S.Y, Yi D.Y. Components of human breast milk: from macronutrient to microbiome and microRNA. Clinical and Experimental Pediatrics, 2020, 63(8): 301-309. https://doi.org/10.3345/cep.2020.00059
Kunz C., Rudolff S. Health promoting aspects of milk oligosaccharides. International Dairy Journal, 2006, 16(11): 1341-1346. https://doi.org/10.1016/j.idairyj.2006.06.020
Li L., Liu X., Guo H. The nutritional ingredients and antioxidant activity of donkey milk and donkey milk powder, Food Science and Biotechnology, 2018, 27(2): 393-400. https://doi.org/10.1007/s10068-017-0264-2
Li Y., Fan Y., Shaikh A.S., Wang Z., Wang D., Tan H. Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes. Journal of Ethnopharmacology, 2020, 246(1): 112221. https://doi.org/10.1016/j.jep.2019.112221
Licitra R., Chessa S., Salari F., Gattolin S., Bulgari O., Altomonte I., Martini M. Milk protein polymorphism in Amiata donkey. Livestock Science, 2019, 230(12): 103845. https://doi.org/10.1016/j.livsci.2019.103845
Lönnerdal B., Erdmann P., Thakkar S.K., Sauser J., Destaillats F. Longitudinal evolution of true protein, amino acids and bioactive proteins in breast milk: A developmental perspective. The Journal of Nutritional Biochemistry, 2017, 41(3): 1-11. https://doi.org/10.1016/j.jnutbio.2016.06.001
Malacarne M., Criscione A., Franceschi P., Bordonaro S., Formaggioni P., Marletta D., Summer A. New insights into chemical and mineral composition of donkey milk hroughout nine months of lactation. Animals, 2019, 9(12): 1161. https://doi.org/10.3390/ani9121161
Malissiova E., Arsenos G., Papademas P., Fletouris D., Manouras A., Aspri M., Nikolopoulou A., Giannopoulou A., Arvanitoyannis I. Assessment of donkey milk chemical, microbiological and sensory attributes in Greece and Cyprus. International Journal of Dairy Technology, 2016, 69(1): 143-146. https://doi.org/10.1111/1471-0307.12245
Mansueto P., Iacono G., Taormina G., Seidita A., D’Alcamo A., Adragna F., Randazzo G., Carta M., Rini G., Carroccio A. Ass’s milk in allergy to cow’s milk protein: a review. Acta Medica Mediterranea, 2013, 29(3): 153-160. Available at: https://core.ac.uk/download/pdf/53285735.pdf
Mao X., Gu J., Sun Y., Xu S., Zhang X., Yang H., Ren F. Anti-proliferative and anti-tumour effect of active components in donkey milk on A549 human lung cancer cells. International Dairy Journal, 2009, 19(11): 703-708. https://doi.org/10.1016/j.idairyj.2009.05.007
Marletta D., Tidona F., Bordonaro S. Chapter 10. Donkey milk proteins: digestibility and nutritional significance, In: Milk Proteins (Isabel Gigli Ed.). InTeth. 2016, pp: 199-209, Print ISBN 978-953-51-2536-5 https://doi.org/10.5772/62597
Martemucci G., D’Alessandro A. G. Fat content, energy value and fatty acid profile of donkey milk during lactation and implications for human nutrition. Lipids in Health and Disease, 2012, 11(9): 113. https://doi.org/10.1186/1476-511X-11-113
Martini M., Altomonte I., Licitra L., Salari F., Short communication: Technological and seasonal variations of vitamin D and other nutritional components in donkey milk. Journal of Dairy Science, 2018, 101(10): 8721-8725. https://doi.org/10.3168/jds.2018-14776
Martini M., Altomonte I., Licitra R., Salari F. Nutritional and Nutraceutical Quality of Donkey Milk. Journal of Equine Veterinary Science, 2018a, 65(6): 33-37. https://doi.org/10.1016/j.jevs.2017.10.020
Martini M., Salari F., Licitra R., La Motta C., Altomonte I. Lysozyme activity in donkey milk. International Dairy Journal, 2019, 96(9): 98-101. https://doi.org/10.1016/j.idairyj.2019.04.009
Martini M., Swiontek K., Antonicelli L., Garritani M.S., Bilò M.B., Mistrello G., Amato S., Revets D., Ollert M., Morisset M., et al. Lysozyme, a new allergen in donkey’s milk. Clinical & Experimental Allergy, 2018a, 48(11): 1521-1523. https://doi.org/10.1111/cea.13232
Massouras T., K. Triantaphyllopoulos A., Theodossiou I. Chemical composition, protein fraction and fatty acid profile of donkey milk during lactation. International Dairy Journal, 2017, 75(12): 83-90. https://doi.org/10.1016/j.idairyj.2017.06.007
Mignone, L.E. Whey protein: The “whey” forward for treatment of type 2 diabetes? World Journal of Diabetes, 2015, 6(14): 1274-1284. https://doi.org/10.4239/wjd.v6.i14.1274
Monti L., Cattaneo T. M. P., Orlandi M., Curadi M. C. Capillary electrophoresis of sialylated oligosaccharides in milk from different species, Journal of Chromatography, 2015, 1409(8): 288-291. http://dx.doi.org/10.1016/j.chroma.2015.07.076
Murua A., Todorov S., Vieira A., Martinez R., Cenciˇc A., Franco B. Isolation and identification of bacteriocinogenic strain of Lactobacillus plantarum with potential beneficial properties from donkey milk. Journal of Applied Microbiology, 2013, 114(6): 1793-1809. http://doi.org/10.1111/jam.12190
Nayak C. M., Ramachandra C. T., Nidoni U., Hiregoudar S., Ram J., Naik N. Physico‐chemical composition, minerals, vitamins, amino acids, fatty acid profile and sensory evaluation of donkey milk from Indian small grey breed. Journal of Food Science and Technology, 2020, 57(8): 2967-2974. https://doi.org/10.1007/s13197-020-04329-1
Nazzaro F., Orlando P., Fratianni F., Coppola R. Isolation of components with antimicrobial property from the donkey milk: a preliminary study. The Open Food Science Journal, 2010, 4(9): 43-47. http://doi.org/10.2174/1874256401004010043
Peeters C., Herman A., Baeck M. Donkey’s milk allergy. British Journal of Dermatology, 2017, 177(6): 1760-1761. http://doi.org/10.1111/bjd.15367
Polidori P., Vincenzetti S. Chapter 8. Protein Profile Characterization of Donkey Milk. In: Milk Protein (Walter Hurley Ed.). 2012, pp. 215-232, ebook ISBN 978-953-51-4278-2 https://doi.org/10.5772/45982
Salimei E., Fantuz F., Varisco G., Maglieri C., Polidori M. Different fibre sources in dairy ass’s diet: effects on milk yield and composition, Italian Journal of Animal Science, 2005, 4 (Suppl. 2): 430-432. https://doi.org/10.4081/ijas.2005.2s.430
Salimei E., Fantuz F., Coppola R., Chiofalo B., Polidori P., Varlsco G. Composition and characteristics of ass's milk, Animal Research, 2004, 53(1): 67-78. https://doi.org/10.1051/animres:2003049
Salimei Е. Animals that Produce Dairy Foods | Donkey. In: Encyclopedia of Dairy Sciences (Second Edition) (John W. Fuquay Ed.). Elsevier Ltd., Academic Press. 2011, pp. 365-373, ISBN: 978-0-12-374407-4
Salimei Е., Chiofalo В. Asses: Milk Yield and Composition. In: Nutrition and Feeding of the Broodmare (N. Miraglia, W. Martin-Rosset Eds.). EAAP Scientific Series, Volume 120. 2006, pp. 117-131. Print ISBN: 978-90-8686-014-2, eISBN: 978-90-8686-584-0, https://doi.org/10.3920/978-90-8686-584-0
Šarić L. C, Šarić B. M., Kravić S.T., Plavšić D. V., Milovanović I. L., Gubić J. M., Nedeljković N. M. Antibacterial activity of domestic Balkan donkey milk toward Listeria monocytogenes and Staphylococcus aureus. Food and Feed Research, 2014a, 41(1): 47-54. Available at: https://scindeks-clanci.ceon.rs/data/pdf/2217-5369/2014/2217-53691401047S.pdf
Šarić L. Ć., Sarić B. M., Mandić A. I., Torbica A. M., Tomić J. M., Cvetković D. D., Okanović D. G. Antibacterial properties of Domestic Balkan donkeys’ milk. International Dairy Journal, 2012, 25(2): 142-146. https://doi.org/10.1016/j.idairyj.2012.03.007
Šarić L., Šarić B., Mandić A., Tomić J., Torbica A., Nedeljković N., Ikonić B. Antibacterial activity of donkey milk against Salmonella. Agro FOOD Industry Hi Tech, 2014b, 25(5): 30-34.
Šarić L., Šarić B., Mandić A., Kevrešan Z. S., Ikonić B. B., Kravić S. Z., Jambrec D. J. Role of calcium content in antibacterial activity of donkeys’ milk toward E. coli. European Food Research and Technology, 2014c, 239(12): 1031-1039. https://doi.org/10.1007/s00217-014-2299-4
Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon-gamma: An overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 2004, 75(2): 163-189. https://doi.org/10.1189/jlb.0603252
Simos Y., Metsios A., Verginadis I., D’Alessandro A.G., Loiudice P., Jirillo E., Charalampidis P., Kouimanis V., Boulaka A., Martemucci G., Karkabounasa S. Antioxidant and anti-platelet properties of milk from goat, donkey and cow: An In Vitro, Ex Vivo and In Vivo study. International Dairy Journal, 2011, 21(11): 901-906. https://doi.org/10.1016/j.idairyj.2011.05.007
Tesse R., Paglialunga C., Braccio S., Armenio L. Adequacy and tolerance to ass's milking an Italian cohort of children with cow's milk allergy, Italian Journal of Pediatrics, 2009, 35(19): 1824-7288-35-19 https://doi.org/10.1186/1824-7288-35-19
Тidona F., Criscione A., Jacobsen M. B., Devold T., Bordonaro S., Vegarud G. E., Marletta D. In vitro digestion of donkey milk with human gastrointestinal enzymes. Book of Abstracts of the 61st Annual Meeting of the European Association for Animal Production, Heraklion - Crete Island, Greece, 2010, p. 42.
Тidona F., Criscione A., Devold T. G., Bordonaro S., Marletta D., Vegarud G. E. Protein composition and micelle size of donkey milk with different protein patterns: Effects on digestibility. International Dairy Journal, 2014, 35(1): 57-62. https://doi.org/10.1016/j.idairyj.2013.10.018
Тidona F., Sekse C., Criscione A., Jacobsen M., Bordonaro S., Marletta D., Vegarud G. E. Antimicrobial effect of donkeys’ milk digested in vitro with human gastrointestinal enzymes. International Dairy Journal, 2011, 21(3): 158-165. https://doi.org/10.1016/j.idairyj.2010.10.008
Trinchese G., Cavaliere G., Canani R.B., Matamoros S., Bergamo P., De Filippo C., Aceto S., Gaita M., Cerino P., Negri R. et al. Human, donkey and cow milk differently affects energy efficiency and inflammatory state by modulating mitochondrial function and gut microbiota. The Journal of Nutritional Biochemistry, 2015, 26(11): 1136-1146. https://doi.org/10.1016/j.jnutbio.2015.05.003
Trinchese G., Cavaliere G., De Filippo C., Aceto S., Prisco M., Chun J.T., Penna E., Negri R., Muredda L., Demurtas A., Banni S., Berni-Canani R., Raso G.M., Calignano A., Meli R., Greco L., Crispino M., Mollica M.P. Human milk and donkey milk, compared to cow milk, reduce inflammatory mediators and modulate glucose and lipid metabolism, acting on mitochondrial function and oleylethanolamide levels in rat skeletal muscle. Frontiers in Physiology 2018, 30(9): 32. https://doi.org/10.3389/fphys.2018.00032
Turganbaeva N., Isakova D. Investigation amino acid composition of donkey’s milk of the Kegety Gorge. Light Industry and Food Industry, 2021, Scientific Collection Interconf(71): 363-369. https://doi.org/10.51582/interconf.19-20.08.2021.034
Valle E., Pozzo L., Giribaldi M., Bergero D., Gennero M. S., Dezzutto D., McLean A., Borreani G., Coppa M., Cavallarinc L. Effect of farming system on donkey milk composition. Journal of the Science of Food and Agriculture, 2018, 98(7): 2801-2808. https://doi.org/10.1002/jsfa.8777
Vincenzetti S., Polidori P., Salimei E., Mariani P. L., Allegri S., Cammertoni N., Quadrini B., Vita A. Purification and Identification of αs1- and β-Caseins from milk. Veterinary Research Communications, 2005a, 29(Suppl. 2): 211-213. https://doi.org/10.1007/s11259-005-0045-x
Vincenzetti S., Polidori P., Fantuz F., Mariani P. L., Cammertoni N., Vita A., Polidori F. Donkey’s milk caseins characterization, Italian Journal of Animal Science, 2005b, 4(Suppl 2): 427-429. https://doi.org/10.4081/ijas.2005.2s.427
Vincenzetti S., Polidori P., Vita A. Chapter 8. Nutritional Characteristics of Donkey’s Milk Protein Fraction, In: Dietary Protein Research Trends (Janet R. Ling Ed.). 2007, pp. 207-225, ISBN: 978-1-60021-607-7
Vincenzetti S., Amici A., Pucciarelli S., Vita A., Micozzi D., Carpi F. M., Polzonett V., Natalini P., Polidori P. A proteomic study on donkey milk. Biochemistry and Analytical Biochemistry, 2012, 1(2): 1000109. http://doi.org/10.4172/2161-1009.1000109
Vincenzetti S., Pucciarelli S., Polzonetti V., Polidori P. Role of proteins and of some bioactive peptides on the nutritional quality of donkey milk and their impact on human health. Beverages, 2017, 3(3): 3030034. http://doi.org/10.3390/beverages3030034
Vincenzetti S., Pucciarelli S., Santini G., Klimanova Y., Polzonetti V., Polidori P. B-Vitamins determination in donkey milk. Beverages, 2020, 6(3): 6030046. http://doi.org/10.3390/beverages6030046
Vincenzetti S., Santini G., Polzonetti V., Pucciarelli S., Klimanova Y., Polidori P. Vitamins in human and donkey milk: Functional and nutritional role, Nutrients, 2021, 13(5): 13051509. https://doi.org/10.3390/nu13051509
Wang F., Chen M., Luo R., Huang G., Wu X., Zheng N., Zhang Y., Wang J. Fatty acid profiles of milk from Holstein cows, Jersey cows, buffalos, yaks, humans, goats, camels, and donkeys based on gas chromatography-mass spectrometry. Journal of Dairy Science, 2022, 105(2): 1687-1700. https://doi.org/10.3168/jds.2021-20750
Weng J., Ji L., Jia W., Lu J., Zhou Z., Zou D., Guo X. Normes de soins pour le diabète de type 2 en Chine. Recherche et Revues sur le Diabetes Metabolism, 2016, 32: 442-458.
Zhang X. Y., Zhao L., Jiang L., Dong M. L., Ren F. Z. The antimicrobial activity of donkey milk and its microflora changes during storage, Food Control, 2008, 19(12): 1191-1195. https://doi.org/10.1016/j.foodcont.2008.01.005
Alabiso M., Giosuè C., Alicata M. L., Mazza F., Iannolino G. The effects of different milking intervals and milking times per day in jennet milk production, Animal, 2008, 3(4): 543-547. https://doi.org/10.1017/S1751731108003753
Alichanidis E., Moatsou G., Polychroniado A. Composition and Properties of Non-cow Milk and Products. In: Non-Bovine Milk and Milk Products. (E. Tsakalidou, K. Papadimitriou Eds.). Elsevier Academic Press. 2016, pp. 81-116, eBook ISBN: 9780128033623 https://doi.org/10.1016/B978-0-12-803361-6.00005-3
Altomonte I., Nardoni S., Mancianti F., Perrucci S., Licitra R., Salari F., Martini M. Preliminary results on antifungal activity of donkey milk. Large Animal Review, 2019a, 25(5): 179-181.
Altomonte I., Salari F., Licitra R., Martini M. Donkey and human milk: Insights into their compositional similarities. International Dairy Journal, 2019, 89(2): 111-118. https://doi.org/10.1016/j.idairyj.2018.09.005
Amati L., Marzulli G., Martulli M., Tafaro A., Jirillo F., Pugliese V., Martemucci G., D’Alessandro A. Donkey and goat milk intake and modulation of the human aged immune response. Current Pharmaceutical Design, 2010, 16(7): 864-869. https://doi.org/10.2174/138161210790883651
Aspri M., Economou N., Papademas P. Donkey milk: An overview on functionality, technology, and future prospects. Food Reviews International, 2017, 33(3): 316-333. https://doi.org/10.1080/87559129.2016.1175014
Aspri M., Leni G., Galaverna G., Papademas P. Bioactive properties of fermented donkey milk, before and after in vitro simulated gastrointestinal digestion. Food Chemistry, 2018, 268(2): 476-484 https://doi.org/10.1016/j.foodchem.2018.06.119
Barłowska J., Szwajkowska M., Litwińczuk Z., Król J., Nutritional value and technological suitability of milk from various animal species used for dairy production, 2011, Comprehensive Reviews in Food Science and Food Safety, 10(6): 291-302. https://doi.org/10.1111/j.1541-4337.2011.00163.x
Brumini D., Criscione A., Bordonaro S., Vegarud G. E., Marletta D. Whey proteins and their antimicrobial properties in donkey milk: a brief review. Dairy Science and Technology, 2015, 96(1): 1-14. https://doi.org/10.1007/s13594-015-0246-1
Carminati D., Tidona F. 2017. Chapter 31. Nutritional value and potential health benefits of donkey milk. In: Nutrients in Dairy and their Implications for Health and Disease (R. R. Watson, R. J. Collier, V.R. Preedy Eds.). Elsevier Inc., Academic Press. 2017. pp. 407-414, Hardcover ISBN: 978-0-12-809762-5, eBook ISBN: 978-0-12-809763-2,
Cavallarin L., Giribaldi M., de los Rio D. S., Valle E., Barbarino G., Gennero M. S., Civera T. A survey on the milk chemical and microbiological quality in dairy donkey farms located in NorthWestern Italy. Food Control, 2015, 50(4): 230-235. https://doi.org/10.1016/j.foodcont.2014.08.019
Chiavari C., Coloretti F., Nanni M., Sorrentino E., Grazia L. Use of donkey’s milk for a fermented beverage with lactobacilli. Le Lait, 2005, 85(6): 481-490. https://doi.org/10.1051/lait:2005031
Criscione A., Cunsolo V., Bordonaro S., Guastella A. M., Saletti R., Zuccaro A., D’Urso G., Marletta D. Donkeys’ milk protein fraction investigated by electrophoretic methods and mass spectrometric analysis. International Dairy Journal, 2009, 19(4): 190-197. https://doi.org/10.1016/j.idairyj.2008.10.015
D’Alessandro A. G., Martemucci G., Jirillo E., De Leo V. Major whey proteins in donkey’s milk: effect of season and lactation stage. Implications for potential dietary interventions in human diseases. Immunopharmacology and Immunotoxicology, 2011, 33(2): 259-265. https://doi.org/10.3109/08923973.2010.499365
Ebrahimi A., Moosavy M., Khatibi S.A., Barabadi Z., Hajibemani A. A comparative study of the antibacterial properties of milk from different domestic animals. International Journal of Dairy Technology, 2021, 74(2): 425-430. https://doi.org/10.1111/1471-0307.12757
Fantuz F., Ferraro S., Todini L., Pilonia R., Mariani P., Salimei E. Donkey milk concentration of calcium, phosphorus, potassium, sodium and magnesium, International Dairy Journal, 2012, 24(2): 143-145. https://doi.org/10.1016/j.idairyj.2011.10.013
Feng P., Gao M., Burgher A., Zhou T.H., Pramuk K. A nine-country study of the protein content and amino acid composition of mature human milk. Food & Nutrition Research, 2016, 60(8): 31042. https://doi.org/10.3402/fnr.v60.31042
Gastaldi D., Bertino E., Monti G., Baro C., Fabris C., Lezo A., Medana C., Baiocchi C., Mussap M., Galvano F., Conti A. Donkey’s milk detailed lipid composition. Frontiers in Bioscience, 2010, 2(2): 537-546. https://doi.org/10.2741/E112
Giosuè C., Alabiso M., Russo G., Alicata M. L., Torrisi C. Jennet milk production during the lactation in a Sicilian farming system. Animal, 2008, 2(10): 1491-1495. https://doi.org/10.1017/S1751731108002231
Gubić J., Tasić T., Tomić J., Torbica A. Determination of whey proteins profile in Balkan donkey’s milk during lactation period. Journal of Hygienic Engineering and Design 2014, 8(1): 178-180. Available at: https://keypublishing.org/jhed/wp-content/uploads/2020/07/11.-Jasmina-Gubić.pdf
Guo H. Y., Pang K., Zhang X. Y., Zhao L., Chen S. W., Dong M. L., Ren F. Z. Composition, physiochemical properties, nitrogen fraction distribution, and amino acid profile of donkey milk. Journal of Dairy Science, 2007, 90(4): 1635-1643. https://doi.org/10.3168/jds.2006-600
Ibrahim H.R., Aoki T. New promises of lysozyme as immune modulator and antimicrobial agent for nutraceuticals. Foods & Food Ingredients Journal of Japan, 2003, 208(5): 361-374.
Ivanković A., Ramljak J., Štulina I., Antunac N., Bašić I., Kelava N., Konjačić M. Characteristics of the lactation, chemical composition and milk hygiene quality of the Littoral-Dinaric ass. Mljekarstvo, 2009, 59(2): 107-113.
Jiang L., Lv J., Liu J., Hao X., Ren F., Guo H. Donkey milk lysozyme ameliorates dextran sulfate sodium-induced colitis by improving intestinal barrier function and gut microbiota composition. Journal of Functional Foods, 2018, 48(9): 144-152. https://doi.org/10.1016/j.jff.2018.07.005
Jirillo F., Magrone T. Anti-inflammatory and anti-allergic properties of donkey’s and goat’s milk. Endocrine, Metabolic & Immune Disorders - Drug Targets, 2014, 14(1): 27-37. https://doi.org/10.2174/1871530314666140121143747
Kapila R., Sharma R., Kapila S. Chapter 22. Milk and Fermented Milk Products in Alleviation of Aging Pathophysiology. In: Dairy in Human Health and Disease Across the Lifespan (R. R. Watson, R. J. Collier, V. R. Preedy Eds). Elsevier, Academic Press. 2017, pp. 287-292, Print ISBN 978-0-12-809868-4 https://doi.org/10.1016/B978-0-12-809868-4.00022-4
Karami Z., Akbari-adergani B. Bioactive food derived peptides: A review on correlation between structure of bioactive peptides and their functional properties. Journal of Food Science and Technology, 2019, 56(2): 535-547. https://doi.org/10.1007/s13197-018-3549-4
Kim S.Y, Yi D.Y. Components of human breast milk: from macronutrient to microbiome and microRNA. Clinical and Experimental Pediatrics, 2020, 63(8): 301-309. https://doi.org/10.3345/cep.2020.00059
Kunz C., Rudolff S. Health promoting aspects of milk oligosaccharides. International Dairy Journal, 2006, 16(11): 1341-1346. https://doi.org/10.1016/j.idairyj.2006.06.020
Li L., Liu X., Guo H. The nutritional ingredients and antioxidant activity of donkey milk and donkey milk powder, Food Science and Biotechnology, 2018, 27(2): 393-400. https://doi.org/10.1007/s10068-017-0264-2
Li Y., Fan Y., Shaikh A.S., Wang Z., Wang D., Tan H. Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes. Journal of Ethnopharmacology, 2020, 246(1): 112221. https://doi.org/10.1016/j.jep.2019.112221
Licitra R., Chessa S., Salari F., Gattolin S., Bulgari O., Altomonte I., Martini M. Milk protein polymorphism in Amiata donkey. Livestock Science, 2019, 230(12): 103845. https://doi.org/10.1016/j.livsci.2019.103845
Lönnerdal B., Erdmann P., Thakkar S.K., Sauser J., Destaillats F. Longitudinal evolution of true protein, amino acids and bioactive proteins in breast milk: A developmental perspective. The Journal of Nutritional Biochemistry, 2017, 41(3): 1-11. https://doi.org/10.1016/j.jnutbio.2016.06.001
Malacarne M., Criscione A., Franceschi P., Bordonaro S., Formaggioni P., Marletta D., Summer A. New insights into chemical and mineral composition of donkey milk hroughout nine months of lactation. Animals, 2019, 9(12): 1161. https://doi.org/10.3390/ani9121161
Malissiova E., Arsenos G., Papademas P., Fletouris D., Manouras A., Aspri M., Nikolopoulou A., Giannopoulou A., Arvanitoyannis I. Assessment of donkey milk chemical, microbiological and sensory attributes in Greece and Cyprus. International Journal of Dairy Technology, 2016, 69(1): 143-146. https://doi.org/10.1111/1471-0307.12245
Mansueto P., Iacono G., Taormina G., Seidita A., D’Alcamo A., Adragna F., Randazzo G., Carta M., Rini G., Carroccio A. Ass’s milk in allergy to cow’s milk protein: a review. Acta Medica Mediterranea, 2013, 29(3): 153-160. Available at: https://core.ac.uk/download/pdf/53285735.pdf
Mao X., Gu J., Sun Y., Xu S., Zhang X., Yang H., Ren F. Anti-proliferative and anti-tumour effect of active components in donkey milk on A549 human lung cancer cells. International Dairy Journal, 2009, 19(11): 703-708. https://doi.org/10.1016/j.idairyj.2009.05.007
Marletta D., Tidona F., Bordonaro S. Chapter 10. Donkey milk proteins: digestibility and nutritional significance, In: Milk Proteins (Isabel Gigli Ed.). InTeth. 2016, pp: 199-209, Print ISBN 978-953-51-2536-5 https://doi.org/10.5772/62597
Martemucci G., D’Alessandro A. G. Fat content, energy value and fatty acid profile of donkey milk during lactation and implications for human nutrition. Lipids in Health and Disease, 2012, 11(9): 113. https://doi.org/10.1186/1476-511X-11-113
Martini M., Altomonte I., Licitra L., Salari F., Short communication: Technological and seasonal variations of vitamin D and other nutritional components in donkey milk. Journal of Dairy Science, 2018, 101(10): 8721-8725. https://doi.org/10.3168/jds.2018-14776
Martini M., Altomonte I., Licitra R., Salari F. Nutritional and Nutraceutical Quality of Donkey Milk. Journal of Equine Veterinary Science, 2018a, 65(6): 33-37. https://doi.org/10.1016/j.jevs.2017.10.020
Martini M., Salari F., Licitra R., La Motta C., Altomonte I. Lysozyme activity in donkey milk. International Dairy Journal, 2019, 96(9): 98-101. https://doi.org/10.1016/j.idairyj.2019.04.009
Martini M., Swiontek K., Antonicelli L., Garritani M.S., Bilò M.B., Mistrello G., Amato S., Revets D., Ollert M., Morisset M., et al. Lysozyme, a new allergen in donkey’s milk. Clinical & Experimental Allergy, 2018a, 48(11): 1521-1523. https://doi.org/10.1111/cea.13232
Massouras T., K. Triantaphyllopoulos A., Theodossiou I. Chemical composition, protein fraction and fatty acid profile of donkey milk during lactation. International Dairy Journal, 2017, 75(12): 83-90. https://doi.org/10.1016/j.idairyj.2017.06.007
Mignone, L.E. Whey protein: The “whey” forward for treatment of type 2 diabetes? World Journal of Diabetes, 2015, 6(14): 1274-1284. https://doi.org/10.4239/wjd.v6.i14.1274
Monti L., Cattaneo T. M. P., Orlandi M., Curadi M. C. Capillary electrophoresis of sialylated oligosaccharides in milk from different species, Journal of Chromatography, 2015, 1409(8): 288-291. http://dx.doi.org/10.1016/j.chroma.2015.07.076
Murua A., Todorov S., Vieira A., Martinez R., Cenciˇc A., Franco B. Isolation and identification of bacteriocinogenic strain of Lactobacillus plantarum with potential beneficial properties from donkey milk. Journal of Applied Microbiology, 2013, 114(6): 1793-1809. http://doi.org/10.1111/jam.12190
Nayak C. M., Ramachandra C. T., Nidoni U., Hiregoudar S., Ram J., Naik N. Physico‐chemical composition, minerals, vitamins, amino acids, fatty acid profile and sensory evaluation of donkey milk from Indian small grey breed. Journal of Food Science and Technology, 2020, 57(8): 2967-2974. https://doi.org/10.1007/s13197-020-04329-1
Nazzaro F., Orlando P., Fratianni F., Coppola R. Isolation of components with antimicrobial property from the donkey milk: a preliminary study. The Open Food Science Journal, 2010, 4(9): 43-47. http://doi.org/10.2174/1874256401004010043
Peeters C., Herman A., Baeck M. Donkey’s milk allergy. British Journal of Dermatology, 2017, 177(6): 1760-1761. http://doi.org/10.1111/bjd.15367
Polidori P., Vincenzetti S. Chapter 8. Protein Profile Characterization of Donkey Milk. In: Milk Protein (Walter Hurley Ed.). 2012, pp. 215-232, ebook ISBN 978-953-51-4278-2 https://doi.org/10.5772/45982
Salimei E., Fantuz F., Varisco G., Maglieri C., Polidori M. Different fibre sources in dairy ass’s diet: effects on milk yield and composition, Italian Journal of Animal Science, 2005, 4 (Suppl. 2): 430-432. https://doi.org/10.4081/ijas.2005.2s.430
Salimei E., Fantuz F., Coppola R., Chiofalo B., Polidori P., Varlsco G. Composition and characteristics of ass's milk, Animal Research, 2004, 53(1): 67-78. https://doi.org/10.1051/animres:2003049
Salimei Е. Animals that Produce Dairy Foods | Donkey. In: Encyclopedia of Dairy Sciences (Second Edition) (John W. Fuquay Ed.). Elsevier Ltd., Academic Press. 2011, pp. 365-373, ISBN: 978-0-12-374407-4
Salimei Е., Chiofalo В. Asses: Milk Yield and Composition. In: Nutrition and Feeding of the Broodmare (N. Miraglia, W. Martin-Rosset Eds.). EAAP Scientific Series, Volume 120. 2006, pp. 117-131. Print ISBN: 978-90-8686-014-2, eISBN: 978-90-8686-584-0, https://doi.org/10.3920/978-90-8686-584-0
Šarić L. C, Šarić B. M., Kravić S.T., Plavšić D. V., Milovanović I. L., Gubić J. M., Nedeljković N. M. Antibacterial activity of domestic Balkan donkey milk toward Listeria monocytogenes and Staphylococcus aureus. Food and Feed Research, 2014a, 41(1): 47-54. Available at: https://scindeks-clanci.ceon.rs/data/pdf/2217-5369/2014/2217-53691401047S.pdf
Šarić L. Ć., Sarić B. M., Mandić A. I., Torbica A. M., Tomić J. M., Cvetković D. D., Okanović D. G. Antibacterial properties of Domestic Balkan donkeys’ milk. International Dairy Journal, 2012, 25(2): 142-146. https://doi.org/10.1016/j.idairyj.2012.03.007
Šarić L., Šarić B., Mandić A., Tomić J., Torbica A., Nedeljković N., Ikonić B. Antibacterial activity of donkey milk against Salmonella. Agro FOOD Industry Hi Tech, 2014b, 25(5): 30-34.
Šarić L., Šarić B., Mandić A., Kevrešan Z. S., Ikonić B. B., Kravić S. Z., Jambrec D. J. Role of calcium content in antibacterial activity of donkeys’ milk toward E. coli. European Food Research and Technology, 2014c, 239(12): 1031-1039. https://doi.org/10.1007/s00217-014-2299-4
Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon-gamma: An overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 2004, 75(2): 163-189. https://doi.org/10.1189/jlb.0603252
Simos Y., Metsios A., Verginadis I., D’Alessandro A.G., Loiudice P., Jirillo E., Charalampidis P., Kouimanis V., Boulaka A., Martemucci G., Karkabounasa S. Antioxidant and anti-platelet properties of milk from goat, donkey and cow: An In Vitro, Ex Vivo and In Vivo study. International Dairy Journal, 2011, 21(11): 901-906. https://doi.org/10.1016/j.idairyj.2011.05.007
Tesse R., Paglialunga C., Braccio S., Armenio L. Adequacy and tolerance to ass's milking an Italian cohort of children with cow's milk allergy, Italian Journal of Pediatrics, 2009, 35(19): 1824-7288-35-19 https://doi.org/10.1186/1824-7288-35-19
Тidona F., Criscione A., Jacobsen M. B., Devold T., Bordonaro S., Vegarud G. E., Marletta D. In vitro digestion of donkey milk with human gastrointestinal enzymes. Book of Abstracts of the 61st Annual Meeting of the European Association for Animal Production, Heraklion - Crete Island, Greece, 2010, p. 42.
Тidona F., Criscione A., Devold T. G., Bordonaro S., Marletta D., Vegarud G. E. Protein composition and micelle size of donkey milk with different protein patterns: Effects on digestibility. International Dairy Journal, 2014, 35(1): 57-62. https://doi.org/10.1016/j.idairyj.2013.10.018
Тidona F., Sekse C., Criscione A., Jacobsen M., Bordonaro S., Marletta D., Vegarud G. E. Antimicrobial effect of donkeys’ milk digested in vitro with human gastrointestinal enzymes. International Dairy Journal, 2011, 21(3): 158-165. https://doi.org/10.1016/j.idairyj.2010.10.008
Trinchese G., Cavaliere G., Canani R.B., Matamoros S., Bergamo P., De Filippo C., Aceto S., Gaita M., Cerino P., Negri R. et al. Human, donkey and cow milk differently affects energy efficiency and inflammatory state by modulating mitochondrial function and gut microbiota. The Journal of Nutritional Biochemistry, 2015, 26(11): 1136-1146. https://doi.org/10.1016/j.jnutbio.2015.05.003
Trinchese G., Cavaliere G., De Filippo C., Aceto S., Prisco M., Chun J.T., Penna E., Negri R., Muredda L., Demurtas A., Banni S., Berni-Canani R., Raso G.M., Calignano A., Meli R., Greco L., Crispino M., Mollica M.P. Human milk and donkey milk, compared to cow milk, reduce inflammatory mediators and modulate glucose and lipid metabolism, acting on mitochondrial function and oleylethanolamide levels in rat skeletal muscle. Frontiers in Physiology 2018, 30(9): 32. https://doi.org/10.3389/fphys.2018.00032
Turganbaeva N., Isakova D. Investigation amino acid composition of donkey’s milk of the Kegety Gorge. Light Industry and Food Industry, 2021, Scientific Collection Interconf(71): 363-369. https://doi.org/10.51582/interconf.19-20.08.2021.034
Valle E., Pozzo L., Giribaldi M., Bergero D., Gennero M. S., Dezzutto D., McLean A., Borreani G., Coppa M., Cavallarinc L. Effect of farming system on donkey milk composition. Journal of the Science of Food and Agriculture, 2018, 98(7): 2801-2808. https://doi.org/10.1002/jsfa.8777
Vincenzetti S., Polidori P., Salimei E., Mariani P. L., Allegri S., Cammertoni N., Quadrini B., Vita A. Purification and Identification of αs1- and β-Caseins from milk. Veterinary Research Communications, 2005a, 29(Suppl. 2): 211-213. https://doi.org/10.1007/s11259-005-0045-x
Vincenzetti S., Polidori P., Fantuz F., Mariani P. L., Cammertoni N., Vita A., Polidori F. Donkey’s milk caseins characterization, Italian Journal of Animal Science, 2005b, 4(Suppl 2): 427-429. https://doi.org/10.4081/ijas.2005.2s.427
Vincenzetti S., Polidori P., Vita A. Chapter 8. Nutritional Characteristics of Donkey’s Milk Protein Fraction, In: Dietary Protein Research Trends (Janet R. Ling Ed.). 2007, pp. 207-225, ISBN: 978-1-60021-607-7
Vincenzetti S., Amici A., Pucciarelli S., Vita A., Micozzi D., Carpi F. M., Polzonett V., Natalini P., Polidori P. A proteomic study on donkey milk. Biochemistry and Analytical Biochemistry, 2012, 1(2): 1000109. http://doi.org/10.4172/2161-1009.1000109
Vincenzetti S., Pucciarelli S., Polzonetti V., Polidori P. Role of proteins and of some bioactive peptides on the nutritional quality of donkey milk and their impact on human health. Beverages, 2017, 3(3): 3030034. http://doi.org/10.3390/beverages3030034
Vincenzetti S., Pucciarelli S., Santini G., Klimanova Y., Polzonetti V., Polidori P. B-Vitamins determination in donkey milk. Beverages, 2020, 6(3): 6030046. http://doi.org/10.3390/beverages6030046
Vincenzetti S., Santini G., Polzonetti V., Pucciarelli S., Klimanova Y., Polidori P. Vitamins in human and donkey milk: Functional and nutritional role, Nutrients, 2021, 13(5): 13051509. https://doi.org/10.3390/nu13051509
Wang F., Chen M., Luo R., Huang G., Wu X., Zheng N., Zhang Y., Wang J. Fatty acid profiles of milk from Holstein cows, Jersey cows, buffalos, yaks, humans, goats, camels, and donkeys based on gas chromatography-mass spectrometry. Journal of Dairy Science, 2022, 105(2): 1687-1700. https://doi.org/10.3168/jds.2021-20750
Weng J., Ji L., Jia W., Lu J., Zhou Z., Zou D., Guo X. Normes de soins pour le diabète de type 2 en Chine. Recherche et Revues sur le Diabetes Metabolism, 2016, 32: 442-458.
Zhang X. Y., Zhao L., Jiang L., Dong M. L., Ren F. Z. The antimicrobial activity of donkey milk and its microflora changes during storage, Food Control, 2008, 19(12): 1191-1195. https://doi.org/10.1016/j.foodcont.2008.01.005
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How to Cite
ZHELEVA, Nikolina Naydenova.
Bioactive components of donkey milk.
Food Science and Applied Biotechnology, [S.l.], v. 5, n. 2, p. 219-231, oct. 2022.
ISSN 2603-3380.
Available at: <https://www.ijfsab.com/index.php/fsab/article/view/212>. Date accessed: 14 oct. 2024.
doi: https://doi.org/10.30721/fsab2022.v5.i2.212.