Exploring the therapeutic potential of cinnamon and clove essential oils for mitigating foodborne diseases: bioactivity and molecular interactions Exploring the therapeutic potential of...
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Abstract
Foodborne diseases remain a global concern due to their widespread impact on public health. Contaminated food can lead to outbreaks of illness that affect millions of people each year, leading to significant economic burdens and strain on healthcare systems. This study delves into the potential of cinnamon and clove essential oils to combat foodborne diseases. Essential oils extracted via the Soxhlet method using ethanol as solvent, these oils exhibit potent antibacterial, anti-inflammatory, antioxidant and anticancer properties. Gas chromatography-mass spectrometry analysis was performed to analyze the chemical constituents in both essential oils. Employing the Lipinski rule, bioactive compounds are screened and docked against a viral replication responsible protein of norovirus and the neurotoxin (botulinum toxin) of Clostridium botulinum both responsible for severe foodborne illnesses. Acetyleugenol demonstrates strong binding affinity, while the pyrimidine derivative from cinnamon sourced from Mbeya, Tanzania forms pi-sulfur interactions with both target molecules. This research emphasizes how essential oils confront foodborne diseases, granting valuable perspectives on potential compounds for extended examination and therapeutic interventions.
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References
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Lin G.M., Chen Y.H., Yen P.L., Chang S.T. Antihyperglycemic and antioxidant activities of twig extract from Cinnamomum osmophloeum. Journal of Traditional and Complementary Medicine, 2016, 6(3): 281-288. https://doi.org/10.1016/j.jtcme.2015.08.005
Manaswini N.K., Nazneen D., Rao G.B.S., Narender B., Vasudha B., Mohan M.R. Evaluation of Ocimumtenuiflorumand Syzygiumaromaticumphenolic ethereal oils for in vitro anti-inflammatory and anti-bacterial activities. Journal of Drug Delivery and Therapeutics, 2019, 9(2): 93-96. https://doi.org/10.22270/jddt.v9i2.2383
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Ogwaro B.A., O’Gara E.A., Hill D.J., Gibson H. The Effect of combined clove and cinnamon extracts on growth and survival of Escherichia fergusonii and Salmonella typhimuriumin milk pre and post fermentation. Journal of Food Science and Nutrition Research, 2022, 5(1): 430-451. https://doi.org/10.26502/jfsnr.2642-11000090
Pettersen E.F., Goddard T.D., Huang C.C., Couch G.S., Greenblatt D.M., Meng E.C., Ferrin T.E. "UCSF Chimera - A Visualization system for exploratory research and analysis. Journal of Computational Chemistry. 2004, 25(13): 1605-1612. https://doi.org/10.1002/jcc.20084.
Praveen A., Risshikaran V., Tamilselvan M., Rameshbabu G.N. Antimicrobial, antioxidant, antiinflammatory analysis of activity and phytochemcial screening of Cinnamomumverum, Acorouscalamus, Cinnamomum cassia, Glyceria labra. World Journal of Pharmaceutical Research, 2018, 7(18): 909-919.
Siejak P., Smułek W., Fathordobady F., Grygier A., Baranowska H.M., Rudzińska M., Masewicz Ł., Jarzębska M., Nowakowski P.T., Makiej A., Kazemian P., Drobnik P., Stachowiak B., Jarzębski M., Pratap-Singh A. Multidisciplinary studies of folk medicine “Five Thieves’ Oil” (Olejek Pięciu Złodziei)Components. Molecules, 2021, 26(10): 2931. https://doi.org/10.3390/molecules26102931
Trott O., Olson J.A. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. Journal of Computational Chemistry, 2010, 31(2): 455-461. https://doi.org/10.1002/jcc.21334
Winder N., Gohar S., Muthana M. Norovirus: An Overview of virology and preventative measures. Viruses,2022, 14(12): 2811. https://doi.org/10.3390/v14122811
Wong Y.C., Ahmad-Mudzaqqir M.Y., Wan-Nurdiyana W.A. Extraction of essential oil from Cinnamon (Cinnamomumzeylanicum). Oriental Journal of Chemistry, 2014, 30(1): 37-47. http://doi.org/10.13005/ojc/300105
Aboukhalaf A., Moujabbir S., El Amraoui B., Naciri K., Kalili A., Essaih S., Rocha J., Belahsen R. Phytochemical screening, nutritional value, antioxidant and antimicrobial activities and acute toxicity of Scolymus hispanicus: A wild edible plant in Morocco. Food Science and Applied Biotechnology, 2023, 6(3): 372-382. https://doi.org/10.30721/fsab2023.v6.i2.248
Adarsh A., Bharath C., Kanthesh B.M., Raghu N. Phytochemical screening and antimicrobial activity of “Cinnamon zeylanicum”. International Journal of Pharmaceutical Research and Innovations, 2020, 13(3): 22-33.
Alwan E.S., Bayoumy M.S., Mohareb R.M. Synthesis of heterocyclic compounds from camphor. Organic Communications, 2023, 16(2): 54-74. http://doi.org/10.25135/acg.oc.150.2303.2741
Bai J., Li J., Chen Z., Chen X., Yang Z., Wang Z., Yang Y. Antibacterial activity and mechanism of clove essential oil against foodborne pathogens. Food Science and Technology, 2023, 173(1): 114249. https://doi.org/10.1016/j.lwt.2022.114249
Brylinski M. Aromatic interactions at the ligand–protein interface: Implications for the development of docking scoring functions. Chemical Biology & Drug Design, 2018, 91(2): 380-390. https://doi.org/10.1111/cbdd.13084
Chavez-Esquivel G., Cervantes-Cuevas H., Ybieta-Olvera L.F., Briones M.C., Acosta D., Cabello J.Antimicrobial activity of graphite oxide doped with silver against Bacillus subtilis, Candidaalbicans, Escherichia coli, and Staphylococcus aureus by agar well diffusion test: Synthesis and characterization. Materials Science and Engineering C, 2021, 123(4): 111934.https://doi.org/10.1016/j.msec.2021.111934
Daeffler K.N.M., Lester H.A., Dougherty D.A. Functionally important aromatic–aromatic and sulfur− π interactions in the D2 dopamine receptor. Journal of the American Chemical Society, 2012, 134(36): 14890-14896. https://doi.org/10.1021/ja304560x
Ghadermazi R., Keramat R., Goli S.A.H. Antioxidant activity of clove (Eugenia caryophyllataThunb), oregano (Oringanumvulgare L.) and sage (Salvia officinalis L.) essential oils in various model systems. International Food Research Journal, 2017, 24(4): 1628-1635. Available at: http://www.ifrj.upm.edu.my/24%20(04)%202017/(38)%20(1).pdf
Gonelimali F.D., Lin J., Miao W., Xuan J., Charles F., Chen M., Hatab S.R. Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Frontiers in Microbiology, 2018, 9(7): 1639. https://doi.org/10.3389/fmicb.2018.01639
Gowtham K., Pranav R.J. Milk dependent hemagglutination inhibition and calcium alginate immobilization of ricin isolated from Ricinus communis L. seeds. Journal of Biological Studies, 2022, 5(4):705-713. https://doi.org/10.62400/jbs.v5i4.7113
Gowtham K., Pranav R.J. Targeting the Bap1 protein of Vibrio cholerae for screening potent inhibitors and predicting the mutant protein stability: in silico analyses. Research Results in Biomedicine, 2024, 10(1):89-98. https://doi.org/10.18413/2658-6533-2024-10-1-0-5
Hari N., Nair V.P. FTIR spectroscopic analysis of lead extract in hexane in Jasminumazoricum L. International Journal of Scientific Research in Science and Technology, 2018, 4(8): 170-172. Print ISSN: 2395-6011, Online ISSN: 2395-602X. Available at: https://ijsrst.com/paper/4472.pdf
Hemalakshmi S., Priyanga S., Devaki K. Fourier transform Infra-Red spectroscopy analysis of Erythrina variegate L. Journal of Pharmaceutical Sciences and Research, 2017, 9(11): 2062-2067. Available at: https://www.jpsr.pharmainfo.in/Documents/Volumes/vol9Issue11/jpsr09111718.pdf
Iwiński H., Różański H., Pachura N., Wojciechowska A., Gębarowski T., Szumny A. In vitro evaluation of antiprotozoal properties, cytotoxicity effect and anticancer activity of new essential-oil based phytoncide mixtures. Molecules, 2023, 28(3): 1395. https://doi.org/10.3390/molecules28031395
Janani K., Ajitha P., Sandhya R., Teja K.V. Chemical constituent, minimal inhibitory concentration, and antimicrobial efficiency of essential oil from Oreganumvulgare against Enterococcus faecalis: An in vitro study. Journal of Conservative Dentistry: JCD, 2019, 22(6): 538-543.Available at: https://journals.lww.com/jcde/fulltext/2019/22060/chemical_constituent,_minimal_inhibitory.7.aspx
Johney J., Sri S.R., Ragunathan R. Extraction of chitin and chitosan from wild Type Pleurotus spp. and its potential application-innovative approach. Journal of Pure and Applied Microbiology, 2018, 12(3): 1631-1640. http://doi.org/10.22207/JPAM.12.3.70
Lee H., Yoon Y. Etiological agents implicated in foodborne illness world wide. Food Science of Animal Resources, 2021, 41(1): 1-7. https://doi.org/10.5851%2Fkosfa.2020.e75
Lin G.M., Chen Y.H., Yen P.L., Chang S.T. Antihyperglycemic and antioxidant activities of twig extract from Cinnamomum osmophloeum. Journal of Traditional and Complementary Medicine, 2016, 6(3): 281-288. https://doi.org/10.1016/j.jtcme.2015.08.005
Manaswini N.K., Nazneen D., Rao G.B.S., Narender B., Vasudha B., Mohan M.R. Evaluation of Ocimumtenuiflorumand Syzygiumaromaticumphenolic ethereal oils for in vitro anti-inflammatory and anti-bacterial activities. Journal of Drug Delivery and Therapeutics, 2019, 9(2): 93-96. https://doi.org/10.22270/jddt.v9i2.2383
Matulja D., Grbčić P., Bojanić K., Topić-Popović N., Což-Rakovac R., Laclef S., Šmuc T.,JovićO., Marković D., Pavelić S.K. Chemical evaluation, antioxidant,antiproliferative, anti-Inflammatoryand antibacterial activities oforganic extract and semi-purifiedfractions of the adriatic sea fan, Eunicellacavolini. Molecules, 2021, 26(19): 5751. https://doi.org/10.3390/molecules26195751
Ogwaro B.A., O’Gara E.A., Hill D.J., Gibson H. The Effect of combined clove and cinnamon extracts on growth and survival of Escherichia fergusonii and Salmonella typhimuriumin milk pre and post fermentation. Journal of Food Science and Nutrition Research, 2022, 5(1): 430-451. https://doi.org/10.26502/jfsnr.2642-11000090
Pettersen E.F., Goddard T.D., Huang C.C., Couch G.S., Greenblatt D.M., Meng E.C., Ferrin T.E. "UCSF Chimera - A Visualization system for exploratory research and analysis. Journal of Computational Chemistry. 2004, 25(13): 1605-1612. https://doi.org/10.1002/jcc.20084.
Praveen A., Risshikaran V., Tamilselvan M., Rameshbabu G.N. Antimicrobial, antioxidant, antiinflammatory analysis of activity and phytochemcial screening of Cinnamomumverum, Acorouscalamus, Cinnamomum cassia, Glyceria labra. World Journal of Pharmaceutical Research, 2018, 7(18): 909-919.
Siejak P., Smułek W., Fathordobady F., Grygier A., Baranowska H.M., Rudzińska M., Masewicz Ł., Jarzębska M., Nowakowski P.T., Makiej A., Kazemian P., Drobnik P., Stachowiak B., Jarzębski M., Pratap-Singh A. Multidisciplinary studies of folk medicine “Five Thieves’ Oil” (Olejek Pięciu Złodziei)Components. Molecules, 2021, 26(10): 2931. https://doi.org/10.3390/molecules26102931
Trott O., Olson J.A. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. Journal of Computational Chemistry, 2010, 31(2): 455-461. https://doi.org/10.1002/jcc.21334
Winder N., Gohar S., Muthana M. Norovirus: An Overview of virology and preventative measures. Viruses,2022, 14(12): 2811. https://doi.org/10.3390/v14122811
Wong Y.C., Ahmad-Mudzaqqir M.Y., Wan-Nurdiyana W.A. Extraction of essential oil from Cinnamon (Cinnamomumzeylanicum). Oriental Journal of Chemistry, 2014, 30(1): 37-47. http://doi.org/10.13005/ojc/300105
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How to Cite
PRANAV, Rithish Jayakumar et al.
Exploring the therapeutic potential of cinnamon and clove essential oils for mitigating foodborne diseases: bioactivity and molecular interactions.
Food Science and Applied Biotechnology, [S.l.], v. 7, n. 1, p. 122-132, mar. 2024.
ISSN 2603-3380.
Available at: <https://www.ijfsab.com/index.php/fsab/article/view/318>. Date accessed: 09 oct. 2024.
doi: https://doi.org/10.30721/fsab2024.v7.i1.318.